The Pathogenesis of a Laboratory Model Resembling the Spectrum Of

There is much to suggest an immunologic basis for some kinds of human glomerulonephritis. The frequent history of streptococcal infection preceding the acute form of this disease with an associated host antistreptococcal response (1), the chronology of clinical events (2), and the usual low levels of serum complement in the acute stage (3), are all consistent with an immunologic disorder. However, in spite of these facts, little is known of the pathogenesis of this disease; i.e., the way in which an immunologic response or responses might lead to kidney injury.